A Korean R&D institute is looking for global partners for automated point-of-care device technology for cardiovascular disease under technical cooperation and research cooperation

Summary

A Korean R&D institute specialised in ICT bio-healthcare has developed an automated biomarker analysis technology, enabling to diagnose cardiovascular disease in the early stage. The technology is more reliable than existing strip-type diagnostic kit and enables diagnostic devices to be miniaturised compared to conventional devices. Any organisation in need of such a technology can be a partner under technical cooperation and research cooperation agreement.

Partner sought

Type of partner sought: SMEs or research institute - Specific area of activity of the partner: medical diagnostic device manufacturing - Task to be performed: Employing the technology to improve the existing medical diagnostic devices. Applying to joint R&D programme(e.g. EUREKA, EUROSTARS) to develop point-of-care medical devices for diagnostics of cancer, virus, and food poisoning.

Description

To diagnose the cardiovascular disease, biomarker-based cardiovascular disease test has normally taken by large medical equipment using ELISA (Enzyme-linked immunosorbent assay) in hospitals or a strip-type diagnostic kit. However, the result obtained from strip-type diagnostic kit shows low reliability and small, medium-sized hospitals or healthcare centres most visited by patients do not have automatic immunological diagnostic device that accurately detect cardiovascular disease biomarkers in the early stage. A Korean R&D institute focusing on ICT Bio-healthcare has developed automatic biomarker analysis technology that diagnoses cardiovascular disease simply and accurately as a Point-of-Care. An automatic analysis device with the technology is microwave-sized, smaller than existing devices. It also takes less than 15 minutes to analyse 5 different biomarkers simultaneously including pre-treatment process of sample and shows high accuracy level of results. The technology invokes the principle that a high-density antibody fixed to the surface of the biochip catches the biomarker in the blood plasma and detects the biomarker as light in specific wavelength, and consists of three specific technologies as below. 1) Signal amplification technology: amplifies the signal, helping in observing light signals generated from antigen-antibody reaction in order to increase the reliability of detecting biomarkers. 2) High-density antibody fixation technology: enables low-concentration protein which is not easily observed to be detected. 3) Rotational motion-based automation technology: minimises the distances among centrifugation, blood sample and mixing for the pre-treatment process. On-site Point-of-Care test device using this technology can not only screen patients with cardiovascular disease easily but predict prospective cardiovascular disease. Thus, it is expected to be used for cardiovascular disease as well as chronic disease and obesity, resulting in improving medical services. The Korean R&D institute is looking for companies or research institutes engaged in medical diagnostic device can be the main partners to improve their products under technical agreement. Also, this institute is interested in applying joint R&D programme(e.g. EUREKA, EUROSTARS) to develop point-of-care medical devices for diagnostics of cancer, virus, and food poisoning under research cooperation agreement.

Advantages and innovations

- Detects 5 different biomarkers simultaneously through automated process, showing the high accuracy of detecting cardiovascular disease (measuring efficiency is less than 10%) - Includes the sample pre-treatment process using centrifugal force - Takes less than 15 minutes detecting biomarkers including pre-treatment - Able to provide inexpensive, high-quality of medical service because of manufacturing devices with lower cost, smaller size than existing diagnostic devices

Development stage

Available for demonstration

Intellectual Property Rights (IPR)

Patents granted

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